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Desk 1 summarizes the noticed DLTs by cohort. Somnolence, which settled in all but one patient, was the only DLT for MLN8054 presented with no methylphenidate or modafinil. The onset of somnolence and its severity usually have been correlated with dose and Cmax. Since somnolence was thought to be related to Cmax, the dosing program was improved fro